More than 40 million adults worldwide, including 3% of U.S. adults, have been diagnosed with bipolar disorder. These people often display higher-than-average levels of creativity, empathy, and resilience, yet, even with these traits, many do not achieve their full potential at work. We believe this results in part from suboptimal aspects of job design, managerial practice, and organizational culture that can be modified to amplify bipolar employees’ effectiveness. In this article, we offer three measures that organizations can take to bring out the best in employees with this condition.